Original articles 

1. Wang J, Li Y, Reguera-Torres, R, Sabri A, Garcia-Fernandez N. Alvarez-Bardon M, Vora L, Lopez-Vidal L, Fuster MG, Luo Y, McCarthy H, Donnelly R, Paredes AJ*. Lymphatic-targeted Amphotericin B Nanocrystals Delivered Using Microarray Patches Applied to Cutaneous Leishmaniasis. Journal of Controlled Release, 386, 114115 (2025). Journal front cover. 

2. Sangalli M, Lopez-Vidal L, Donnelly R, Paredes AJ*. Sub-150 nm drug nanocrystals produced using a milligram-scale media mill. International Journal of Pharmaceutics, 684, 126142 (2025). 

3. Gowda B, Pandya A, Gade S, Duncan R, Paredes AJ, Ahmed M, Yiwei T, Donnelly RF, Singh Thakur R, Vora L. Voriconazole nanosuspension-loaded ocular bilayer dissolving microneedle patch for the management of fungal keratitis. Drug Delivery and Translational Research, Dec (2025). 

4. Cong Y, Li H, Pandya A, Vora L, Li Y, Volpe-Zanutto F, Paredes AJ, Abraham A, Gao J, Larrañeta E, Qin N, Luo Y, Tao Y, Quinn B, McCarthy H, Donnelly R. Nanocrystal-loaded dissolving microneedles: A novel transdermal strategy for long-acting tizanidine administration. Mat Today Adv, 28, 100650 (2025). 

5. Abraham A, Anjani Q, Preis A, Naser Y, bender L, Bar F, Bakowsky U, Catlin E, Paredes A, Vora L, Larrañeta E, Donnelly R. Nano-PhotoCrystals (Photosensitive Nanocrystals) of Aloe Emodin Combined with Dissolving Microneedles for Dual Smart Targeting of Acute Bacterial Skin and Soft Tissue Infections. ACS Applied Materials Interfaces, in press (2025). 

6. Lopez-Vidal L, Bordon G, Paredes AJ*. Super-fast production of drug nanocrystals: Dual asymmetric centrifugation-enabled media milling applied to high throughput formulation screening. Materials & Design, 255, 114216 (2025). 

7. Lopez-Vidal L, Juskaite K, Fandino, O, Garcia-Fuster M, Sangalli M, Adhami M, Wang J, Palma SD, Volpe-Zanutto F, Larrañeta E, Paredes AJ*. 3D-printed acyclovir nanocrystals: An advanced approach to herpes simplex treatment. Applied Materials Today, 44, 102695 (2025). Journal front cover. 

8. Li M, Sabri, A, Qin N, Peng K, Abbate M, Paredes AJ, McCarthy H, Vora L, Donnelly R. Bimodal dissolving microneedles with nanoparticle coating and encapsulation for extended dual-drug delivery. Small, 2502904 (2025).  

9. Lopez-Vidal L, Tinti M, Melian M, Canton L, Lorenzutti M, Schofs L, Formica M, Paredes AJ, Sanchez Bruni S, Litterio N, Faccio R, Palma SD, Real JP. In vivo pharmacokinetic study and PBPK modelling: Comparison between 3D-printed nanocrystals and solid dispersions. International Journal of Pharmaceutics, 669, 125063 (2025).  

10. Fandino O, Hutton A, Zhang C, Abbate M, Naser Y, Li Y, Paredes AJ*, Donnelly R*. Application of microarray patches for the transdermal administration of psychedelic drugs in micro-doses. European Journal of Pharmaceutics and Biopharmaceutics, 207, 114603 (2025). 

11. Awde-Alfonso H, Tártara L, Paredes AJ, Palma SD, Formica ML. Enhanced in vivo performance of topical ocular acetazolamide nanocrystals: A novel approach for glaucoma treatment. International Journal of Pharmaceutics, 674, 125440 (2025). 

12. Yalcin T, Anjani Q, Li Y, Larraneta E, Paredes AJ, Donnelly R. Rasagiline mesylate-based microneedle patches: A patient-friendly treatment regimen for Parkinson’s disease. International Journal of Pharmaceutics, 683, 126019 (2025). 

13. Graham A, Anjani Q, Holm R, Lathuile A, Paredes AJ, Donnelly R. Versatile and sensitive dual-detection HPLC method for rapid quantification of apomorphine hydrochloride: Application to ex vivo percutaneous permeation and deposition studies utilising novel transdermal pressure-sensitive adhesive patches. Drug Delivery and Translational Research, July (2025). 

14. Rodríguez ML, Rosano F, Schiavo A, Tappin A, Paredes AJ, Malanga A, Ibarra M, Fagiolino P, Palma S. QbD-Based Development of Extended-Release Floating Furosemide Tablets: Formulation and In Vitro/In Vivo Evaluation. Journal of Drug Delivery Science and Technology, 113, 107396 (2025). 

15. Catlin E, Fandino, O, Lopez-Vidal L, Sangalli M, Donnelly R, Palma SD, Paredes AJ*. A novel temperature-controlled media milling device to produce drug nanocrystals at the laboratory scale. International Journal of Pharmaceutics, 666, 124780 (2024). 

16. Zhang C, Lopez-Vidal L, Wang J, Himawan A, Donnelly RF, Paredes AJ*. Mucoadhesive Itraconazole Nanocrystals with Precise Control of Surface Charge Incorporated to Chitosan Films for Buccal Drug Delivery. Advanced Therapeutics, 2400209, 1-15 (2024). 

17. Udabe J, Martin-Saldaña S, Tao Y, Picchio M, Beloqui A, Paredes AJ*, Calderón M*. Unveiling the Potential of Surface Polymerized Drug Nanocrystals in Targeted Delivery. ACS Applied Materials Interfaces, 16, 36: 47124–47136 (2024). 

18. Naser Y, Vora L, Tekko I, Peng K, Volpe-Zanutto F, Greer B, Paredes AJ, McCarthy H, Donnelly RF. Atorvastatin-Loaded Dissolving Microarray Patches for Long-acting Microdepot Delivery: Comparison of Nanoparticle and Microparticle Drug Formulations. ACS Applied Materials Interfaces, 16, 41: 55027–55044 (2024).  

19. Ruggeri M, De Luca F, Ungolo A, Vigani B, Paredes AJ, Russo E, Bottone M, Biachi E, Rossi S, Sandri G. Olive mill wastewater: From by-product to smart antioxidant material. International Journal of Pharmaceutics X. November, 100301 (2024). 

20. Qin N, Li M, Vora L, Peng K, Bin Sabri A, Tao Y, Paredes AJ, McCarthy H, Donnelly R. Enhanced long-acting simvastatin delivery via effervescent powder-carrying hollow microneedles and nanocrystal-loaded microneedles. International Journal of Pharmaceutics, 124691 (2024).  

21. Fuster M, Wang J, Fandino O, Villora G, Paredes AJ*. Folic acid-decorated nanocrystals as highly loaded Trojan horses to target cancer cells. Molecular Pharmaceutics, 21, 6: 2781–2794 (2024).  

22. Li Y, Wang J, Kumar L, Sabri A, McGuckin M, Paredes AJ, Donnelly R. Dissolving microarray patches loaded with a rotigotine nanosuspension: A potential alternative to Neupro® patch. Journal of Controlled Release, 372, 304-317 (2024). 

23. Ghanma R, Nasser Y, Anjani Q, Bin Sabri, Hutton A, Kumar L, Himawan A, Moreno-Castellanos N Greer B, McCarthy H, Paredes AJ, Donnelly R. Dissolving microarray patches for transdermal delivery of risperidone for schizophrenia management. International Journal of Pharmaceutics, 660, 20, 124342 (2024) 

24. Zhao L, Li L, Larrañeta E, Paredes AJ, Donnelly R. Novel long-acting treatment for schizophrenia based on paliperidone dissolving and implantable microarray patches. European Journal of Pharmaceutics and Biopharmaceutics, 204, 114481 (2024).  

25. Zhang C, Wu Y, Hutton A, Bin Sabri A, Hibson J, Savage A, McCarthy H, Paredes AJ, Owen A, Rannard S, Donnelly R. Systemic delivery of bictegravir and tenofovir alafenamide using dissolving microneedles for HIV preexposure prophylaxis. International Journal of Pharmaceutics, 660, 124317 (2024).  

26. Pensel P, Scioscia N, Nieto N, Zoppi J, Chapparo M, Paredes AJ, Albani C, Palma SD, Elissondo C Usefulness of a murine model of hepatic cystic echinococcosis for preclinical drug trials: efficacy of albendazole vs albendazole nanocrystals. Acta Tropica, 257, 107285 (2024). 

27. Li M, Vora L, Peng K, Sabri, A, Qin N, Abbate M, Paredes AJ, McCarthy H, Donnelly R. Novel nano-in-micro fabrication technique of diclofenac nanoparticles loaded microneedle patches for localised and systemic drug delivery. Biomaterials Advances, 161, 213889 (2024).  

28. Dai X, Vora L, Permana D, Li M, Habibie, Amir M, Peng K, Zhang C, Daic H, Paredes AJ, Donnelly R. Calcipotriol nanosuspension-loaded trilayer dissolving microneedle patches for the treatment of psoriasis: In vitro delivery and in vivo antipsoriatic activity studies. Molecular Pharmaceutics, 3;21(6):2813-2827 (2024).  

29. McGuckin M, Hutton A, Davis E, Sabri A, Ripolin A, Himawan A, Naser Y, Ghanma R, Greer B, McCarthy H, Paredes AJ, Donnelly R. Transdermal delivery of pramipexole using microneedle technology for the potential treatment of Parkinson’s. Molecular Pharmaceutics, 21, 5: 2512–2533 (2024). 

30. Ramöller IK, Volpe-Zanutto F, Vora LK, Abbate M, Hutton A, McKenna P, Peng K, Tekko I, Sabri A, McAlister E, McCarthy H, Paredes AJ, Donnelly RF. Intradermal delivery of the antiretroviral drugs cabotegravir and rilpivirine by dissolving microarray patches: Investigation of lymphatic uptake. Journal of Controlled Release, 366: 548-566 (2024). 

31. Rossetti A, Real D, Barrientos B, Allemandi D, Paredes AJ, Real J, Palma SD. Significant progress in improving Atorvastatin dissolution rate: Physicochemical characterization and stability assessment of self-dispersible Atorvastatin/Tween 80® nanocrystals formulated through wet milling and freeze-drying. International Journal of Pharmaceutics, 650, 123720 (2024). 

32. Mura P, Cirri M, Rossetti A, Allemandi D, Paredes AJ, Palma S. Preparation of glyburide nanocrystals with improved dissolution properties by dry-ball- and wet-bead- milling: Systematic comparison by experimental design of the performance of the two methods. Journal of Drug Delivery Science Technology, 91: 105222 (2024). 

33. Lopez-Vidal L, Parodi P, Actis M, Camacho N, Real A, Paredes AJ, Irazoqui F, Real JP, Palma SD. Formulation and optimization of pH-sensitive nanocrystals for improved oral delivery. Drug Delivery and Translational Research, 14: 1301-1318 (2024).  

34. Zhang C, Akhter S, Zhang J, Bianchi MB, Volpe-Zanutto F, Baviskar S, Rodriguez-Abetxuko A, Raghu R, Donnelly R, Larrañeta E, Paredes AJ*. Curcumin nanocrystals-in-nanofibers as a promising platform for the management of periodontal disease.  International Journal of Pharmaceutics, 648, 123585 (2023).  

35. Zhang C, Vora L, Tekko I, Volpe-Zanutto F, Peng K, Paredes AJ, McCarthy H, Donnelly R. Development of dissolving microneedles for intradermal delivery of the long-acting antiretroviral drug bictegravir, International Journal of Pharmaceutics, 642, 123108 (2023).  

36. McKenna P, Abbate M, Vora L, Sabri A, Peng K, Volpe-Zanutto F, Tekko I, Permana A, Maguire C, Dineen D, Kearney M, Larrañeta E, Paredes AJ, Donnelly R. Polymeric Microarray Patches for Enhanced Transdermal Delivery of the Poorly Soluble Drug Olanzapine, ACS Applied Materials Interfaces, 15, 31300–31319 (2023).  

37. Abbate M, Ramöller I, Sabri A, Paredes AJ, Hutton A, McKenna P, Peng K, Hollett J, McCarthy H, Donnelly R. Formulation of antiretroviral nanocrystals and development into a microneedle delivery system for potential treatment of HIV-associated neurocognitive disorder (HAND). International Journal of Pharmaceutics, 640, 123005 (2023).  

38. Lopez-Vidal L, Paredes AJ, Palma S, Real JP. Design and Development of Sublingual Printlets Containing Domperidone Nanocrystals Using 3D Melting Solidification Printing Process (MESO-PP). Pharmaceutics, 14, 1459 (2023).  

39. AL Qtaish N, Villate-Beitia I, Gallego I, Martínez-Navarrete G, Soto-Sánchez C, Sainz-Ramos M, Lopez-Mendez Y, Paredes AJ, Chichón J, Zamarreño N, Fernández E, Puras G, Luis Pedraz JL. Long-term biophysical stability of nanodiamonds combined with lipid nanocarriers for non-viral gene delivery to the retina. International Journal of Pharmaceutics, 639: 122968 (2023).  

40. Formica ML, Awde Alfonso H, Paredes AJ, Melian ME, Camacho N, Faccio R, Tártara L, Palma SD. Development of Triamcinolone Acetonide Nanocrystals for Ocular Administration. Pharmaceutics, 15, 2:683 (2023).  

41. Faizi H, Vora L, Nasiri M, Wu Y, Mishra D, Anjani Q, Paredes AJ, Thakur R, Minhas M, Donnelly RF. Deferasirox Nanosuspension Loaded Dissolving Microneedles for Intradermal Delivery. Pharmaceutics, 14, 12:281 (2022).  

42. Paredes AJ. Permana AD, Volpe-Zanutto F, Amir N, Vora L, Tekko I, Akhavein N, Weber A, Larrañeta E, Donnelly RF. Ring inserts as a useful strategy to prepare tip-loaded microneedles for long-acting drug delivery with application in HIV pre-exposure prophylaxis. Materials & Design, 26, 111416 (2022). 

43. M.B. Bianchi, C. Zhang, E. Catlin, G. Sandri, M. Calderón, E. Larrañeta, R.F. Donnelly, M.L. Picchio, Paredes AJ*. Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues. Materials Today Bio, 17, 100471 (2022).  

44. Demartis S, Kurnia Anjani Q, Volpe-Zanutto F, Paredes AJ, Jahan SA, Vora LK, Donnelly RF, Gavini E. Trilayer dissolving polymeric microneedle array loading Rose Bengal transfersomes as a novel adjuvant in early-stage cutaneous melanoma management. International Journal of Pharmaceutics, 627, 122217 (2022).  

45. Campra N, Reinoso E, Moliva M, Montironi I, Raviolo J, Ruiz Moreno F, Marin C, Camacho M, Paredes AJ, Moran M, Estein S, Maletto B, Palma SD, Cariddi L. Spray-drying-microencapsulated Minthostachys verticillata essential oil and limonene as innovative adjuvant strategy to bovine mastitis vaccines. Research in Veterinary Science, 149: 136-150 (2022).  

46. Volpe-Zanutto F, Vora L, Tekko I, McKenna P, Permana A, Sabri A, Anjani Q, McCarthy H, Paredes AJ, Donnelly R. Hydrogel-forming microarray patches with cyclodextrin drug reservoirs for long-acting delivery. Journal of Controlled Release, 348:771-785 (2022). 

47. Picco C, Dominguez J, Utomo E, Paredes AJ, Volpe-Zanutto F, Malinova D, Donelly RF, Larrañeta E. 3D-printed implantable devices with biodegradable rate-controlling membrane for sustained delivery of hydrophobic drugs. Drug Delivery, 29, 1:1038-1048 (2022). 

48. Wu Y, Vora L, Mishra D, Adrianto M, Gade S, Paredes AJ, Donnelly R, Thakur R. Nanosuspension-loaded dissolving bilayer microneedles for hydrophobic drug delivery to the posterior segment of the eye. Material Science and Engineering: C, 137: 212767 (2022). 

49. AL Qtaisha N, Gallego I, Paredes AJ, Villate- Beitia I, Soto-Sánchez C, Martínez-Navarrete G, Sainz-Ramos M, Lopez-Mendez TB, Fernández E, Puras G, Pedraz JL. Nanodiamonds integration into niosomes as an emerging and efficient gene therapy nanoplatform for central nervous system diseases. ACS Applied Materials Interfaces, 639, 122968 (2022). 

50. Ramöller IK, Abbate M, Vora LK, Hutton A, Peng K, Volpe-Zanutto F, Tekko I, Moffatt K, Paredes AJ, McCarthy H, Donnelly RF. HPLC-MS method for simultaneous quantification of the antiretroviral agents rilpivirine and cabotegravir in rat plasma and tissues. Journal of Pharmaceutic and Biomedical Analysis, 213, 114698 (2022). 

51. Paredes AJ, Volpe-Zanutto F, Vora L, Tekko I, McCarthy H, Donnelly R. Systemic delivery of tenofovir alafenamide using dissolving and implantable microneedle patches. Materials Today Bio, 13, 100217 (2022). 

52. Melian-Furest ME, Ibarra M, Ceballos L, Paredes AJ, Munguía B, Faccio R, Palma SD, Álvarez L, Domínguez L. Improving the in vitro dissolution rate and pharmacokinetic performance of fenbendazole in sheep using drug nanocrystals. Research in Veterinary Science, 142: 110-116 (2021). 

53. Lopez-Vidal L, Real JP, Real DA, Camacho N, Kogan M, Paredes AJ, Palma SD. Nanocrystal-based 3D-printed tablets: Melting solidification printing process (MESO-PP) for Oral Administration of poorly soluble drugs. International Journal of Pharmaceutics, 611, 121311 (2021). 

54. Volpe-Zanutto F, Fonseca-Santos B, McKenna P, Paredes AJ, McCrudden M, Dávila J, Marucci Pereira Tangerina M, Ceccheto Figueiredo M, Camargo L, Vilegas W, Brisibe A, d’Ávila, Donnelly R, Chorilli M, Foglio M. Novel transdermal bioadhesive surfactant-based system for release and solubility improvement of antimalarial drugs Artemether-Lumefantrine. Biomedical Materials, 16, 6, 065015 (2021). 

55. Permana A, Paredes AJ, Volpe-Zanutto F, Amir M, Nur, Ismail I, Bahar M, Akbar, Sumarheni S, Palma SD, Donnelly RF. Albendazole nanocrystal-based dissolving microneedles: A promising approach for intradermal delivery with improved pharmacokinetic performance for enhanced treatment of cystic echinococcosis. ACS Applied Materials Interfaces, 13, 32: 38745–38760 (2021). 

56. Paredes AJ, Volpe-Zanutto F, Permana AD, Murphy A, Picco C, Vora L, Coulter J, Donnelly R. Novel tip-loaded dissolving and implantable microneedle array patches for sustained release of finasteride. International Journal of Pharmaceutics, 606, 120885 (2021). 

57. Bordón MG, Paredes AJ, Camacho NM, Pencil MC, González A, Palma SD, Ribotta PD, Martinez ML. Formulation, spray drying and physico-chemical characterization of functional powders loaded with chia seed oil and prepared by complex coacervation. Powder Technology, 391: 479-493 (2021).  

58. Volpe-Zanutto F, Tiburcio-Ferreira L, Permana A, Kirkby M, Paredes AJ, Vora L, Bonfanti A, Charlie-Silva I, Raposo C, Figueiredo MC, Souza IMO, Brisibe A, Maranhão-Costa F, Donnelly RF, Foglio MA. Artemether and lumefantrine dissolving microneedle patches with improved pharmacokinetic performance and antimalarial efficacy in mice infected with Plasmodium yoelii. Journal of Controlled Release, 333: 298-315 (2021).  

59. Permana A, Kurnia Anjani Q, Sartini, Utomo E, Volpe-Zanutto F, Paredes AJ, Mulsiani Evary Y, Mardikasari A, Rezky Pratama M, Nurfadilah Tuany I, Donnelly RF. Selective delivery of silver nanoparticles for improved treatment of biofilm skin infection using bacteria-responsive microparticles loaded into dissolving microneedles. Accepted for publication. Materials Science and Engineering: C, 120, 111786 (2021). 

60. Melian E, Paredes AJ, Munguía B, Colobbio M, Ramos JC, Teixeira R, Manta E, Palma S, Faccio R, Domínguez L. Nanocrystals of novel valerolactam-fenbendazole hybrid with improved biopharmaceutical behaviour. AAPS PharmSciTech, 21, 237: 1-15 (2020). 

61. Permana, A, Paredes AJ, Volpe-Zanutto F, Anjani Q, Utomo E, Donnelly R. Dissolving microneedle-mediated dermal delivery of itraconazole nanocrystals for improved treatment of cutaneous candidiasis. European Journal of Pharmaceutics and Biopharmaceutics, 154: 50-61 (2020). 

62. Camiletti B, Camacho N, Paredes AJ, Allemandi, D, Palma S, Grosso R. Self-dispersible nanocrystals of azoxystrobin and cyproconazole with increased efficacy against soilborne fungal pathogens isolated from peanut crops. Powder Technology, 372: 455-465 (2020).  

63. Paredes AJ, Camacho N, Schofs L, Dib A, Zarazaga M, Litterio N, Allemandi D, Sánchez Bruni S, Lanusse C, Palma S. Ricobendazole nanocrystals obtained by media milling and spray drying: pharmacokinetic comparison with the micronized form of the drug. International Journal of Pharmaceutics, 585:119501 (2020).  

64. Aloisio C, Bueno MS, Ponce Ponte M, Paredes AJ, Palma SD, Longhi M. Development of solid self-emulsifying drug delivery systems (SEDDS) to improve the solubility of resveratrol. Therapeutic Delivery, 10(10): 626-641 (2019). 

65. Martin MP, Riveros CG, Paredes AJ, Allemandi DA, Nepote V, Grosso NR. A Natural Peanut Edible Coating Enhances the Chemical and Sensory Stability of Roasted Peanuts. Journal of Food Science, 84(6): 1529-1537 (2019). 

66. Simonazzi A, Cid GA, Paredes AJ, Gonzo E, Palma SD, Bermudez JM. Development and in vitro evaluation of solid dispersions as strategy to improve albendazole biopharmaceutical behavior. Therapeutic Delivery, 9(9): 623-638 (2018). 

67. Paredes AJ, Litterio N, Dib A, Allemandi DA, Lanusse C, Sanchez Bruni S and Palma SD. A nanocrystal-based formulation improves the pharmacokinetic performance and therapeutic response of albendazole in dogs. Journal of Pharmacy and Pharmacology, 70: 51–58 (2018). 

68. Pensel PE, Paredes AJ, Albani CM, Sanchez Bruni S, Allemandi DA, Elissondo MC, Palma SD. Albendazole nanocrystals improve the chemoprophylactic activity against secondary alveolar echinococcosis in mice. Veterinary Parasitology, 51: 78–84 (2018). 

69. Paredes AJ, Sánchez Bruni S, Allemandi DA, Lanusse C and Palma SD. Albendazole nanocrystals with improved pharmacokinetic performance in mice. Therapeutic Delivery, 9(2), 89-97 (2018). 

70. Picchio ML, Paredes AJ, Palma SD, Passeggi MC, Gugliotta LM, Minari RJ, Alvarez Igarzabal C. pH-Responsive casein-based films and their application as functional coatings in solid dosage formulations. Colloids and Surfaces A, 541: 1-9 (2018). 

71. Vanden Braber NL, Paredes AJ, Rossi YE, Porporatto C, Allemandi DA, Borsarelli CD, Correa SG, Montenegro MA. Controlled release and antioxidant activity of chitosan or its glucosamine water-soluble derivative microcapsules loaded with quercetin. International Journal of Biological Macromolecules, 112: 399–404 (2018). 

72. Asensio CM, Paredes AJ, Martin MP, Allemandi DA, Nepote V, Grosso NR. Antioxidant stability study of oregano essential oil microcapsules prepared by spray‐drying. Journal of Food Science, 82(12): 2864-2872 (2017). 

73. Paredes AJ, Llabot JM, Sanchez Bruni S, Allemandi DA and Palma SD. Self-dispersible nanocrystals of albendazole produced by high pressure homogenization and spray drying. Drug Development and Industrial Pharmacy, 42(10): 1564–70 (2016). 

74. González A, Martinez ML, Paredes AJ, León AE, Ribotta PD. Study of the preparation process and variation of wall components in chia (salvia hispanica l.) oil microencapsulation. Powder Technology, 301: 868–75 (2016). 

75. Tarragona S, Salomón C, Jiménez-Kairuz A, Lamas M, Orlandi S, Leonardi D, Maggia N, Paredes AJ, Romañuk C, García M. Design and preparation of solid dosage forms of benznidazol for the treatment of Chagas Disease. Revista Argentina de Salud Pública, Ministerio de Salud de la Nación Argentina. 4(15): 6-13 (2013). 

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Review articles

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1. Catlin E, Lopez-Vidal L, Donnelly R, Paredes AJ*. A dynamic duo comes of age: Nanocrystals and microneedles for hydrophobic drug delivery. Expert Opinion on Drug Delivery, 22(10):1509-1526, (2025). 

2. Paul A, Lopez-Vidal L, Paredes AJ*. Progress in the Production of Nanocrystals through Miniaturised Milling Methods. RPS Pharmacy and Pharmacology Reports, 4(3), rqaf008 (2025). 

3. Lopez-Vidal L, Juskaite K, Ramoller I, McKenna P, Priotti J, Donnelly R, Paredes AJ*. Advanced Drug Delivery Systems for Treating Local Conditions. Therapeutic Delivery, 16(3):285-303 (2025). 

4. Vora L, Sabri A, McKenna P, Himawan A, Hutton A, Detamornrat U, Paredes AJ, Larrañeta E, Donnelly R. Microneedle-based biosensing. Nature Reviews Bioengineering, 2, 64-81 (2024). 

5. Glover K, Mishra D, Gade S, Vora L, Wu Y, Paredes AJ, Donnelly, Thakur R. Microneedles for advanced ocular drug delivery. Advanced Drug Delivery Reviews, 201, 115082 (2023). 

6. Vora L, Sabri A, Naser Y, Himawan A, Hutton A, Anjani Q, Volpe-Zanutto F, Mishra D, Li M, Rodgers A, Paredes AJ, Larrañeta E, Thakur R, Donnelly R. Long-acting microneedle formulations, Advanced Drug Delivery Reviews, 201, 115055 (2023).  

7. Formica ML, Real D, Picchio M, Catlin E, Donnelly R, Paredes AJ*. On a highway to brain: A review on nose-to-brain drug delivery using nanoparticles. Applied Materials Today, 29, 101631 (2022). Journal’s top cited article. 

8. McGuckin M, Wang J, Ghanma R, Qin, Palma SD, Donnelly RF, Paredes AJ*. Nanocrystals as a master key to deliver hydrophobic drugs via multiple administration routes. Journal of Controlled Release, 345: 334-353 (2022). 

9. McAlister E, Kirkby M, Dominguez-Robles J, Paredes AJ, Anjani Q, Moffatt K, Vora LK, Hutton A, McKenna P, Larraneta E, Donnelly RF. The role of microneedle arrays in drug delivery and patient monitoring to prevent diabetes induced fibrosis. Advanced Drug Delivery Reviews, 175: 113825 (2021). 

10. Paredes AJ, Ramöller I, McKenna P, Abbate M, Volpe-Zanutto F, Vora L, Kilbourne-Brook M, Jarrahian C, Moffatt K, Zhang C, Tekko I, Donnelly RF. Microarray patches: breaking down the barriers to contraceptive care and HIV prevention for women across the globe. Advanced Drug Delivery Reviews, 173: 331-348 (2021). 

11. Vora L, Moffatt K, Tekko I, Paredes AJ, Volpe-Zanutto F, Mishra D, Peng K, Singh Thakur R, Donnelly RF. Microneedle array systems for long-acting drug delivery. European Journal of Pharmaceutics and Biopharmaceutics, 159: 44-76 (2021). Journal’s Most cited paper Award 2024. 

12. Paredes AJ, McKenna P, Ramöller I, Naser Y, Volpe-Zanutto F, Li M, Abbate M, Zhao L, Zhang C, Abu-Ershaid J, Dai X, Donnelly RF. Microarray Patches: Poking a Hole in the Challenges Faced When Delivering Poorly Soluble Drugs. Advanced Functional Materials, 31, 202005792: 1-27 (2021). 

13. Paredes AJ, Asensio CM, Llabot JM, Palma SD, Allemandi DA. Nanoencapsulation in the food industry: manufacture, application and characterization. Journal of Food Bioengineering and Nanoprocessing, 1(1): 56–79 (2016). 

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Books edited 

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1. Nanocrystals: A Universal Tool for the Formulation of Poorly Soluble Drugs. Alejandro J Paredes, Editor. Springer Nature Switzerland AG. ISBN: 9783032102379, February 2026.  

2. Hydrogels in Drug Delivery. Alejandro J Paredes, Eneko Larrañeta, Garry Laverty, Ryan F. Donnelly, Editors. Elsevier, Amsterdam, The Netherlands. ISBN: 9783032102379, March 2025.  

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Book chapters 

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1. Lopez-Vidal L, Catlin E, Paredes AJ*. Nanocrystals: Fundamentals of the technology and its application in drug delivery. In Nanocrystals: A Universal Tool for the Formulation of Poorly Soluble Drugs. Springer Nature Switzerland AG. ISBN: 9783032102379, February 2026. 

2. Lopez-Vidal L, Londoño P, Rossetti A, Real JP, Paredes AJ*, Palma SD*. Nanocrystals: Enhancing the oral bioavailability of poorly-soluble drugs. In Nanocrystals: A Universal Tool for the Formulation of Poorly Soluble Drugs. Springer Nature Switzerland AG. ISBN: 9783032102379, February 2026. 

3. Abraham A, Paul A, Londoño P, Al Jayyousi A, Fuster MG, Battistini F, Paredes AJ*. Nanocrystals for transdermal drug delivery and hair follicle targeting. In Nanocrystals: A Universal Tool for the Formulation of Poorly Soluble Drugs. Springer Nature Switzerland AG. ISBN: 9783032102379, February 2026. 

4. Sousa C, Moreira D, Lopez-Vidal L, Paredes AJ*. Parenteral administration of drug nanocrystals: The role of long-acting injectables. In Nanocrystals: A Universal Tool for the Formulation of Poorly Soluble Drugs. Springer Nature Switzerland AG. ISBN: 9783032102379, February 2026. 

5. Lopez-Vidal L, Catlin E, Donnelly R, Paredes AJ*. Microneedle-mediated administration of drug nanocrystals. In Nanocrystals: A Universal Tool for the Formulation of Poorly Soluble Drugs. Springer Nature Switzerland AG. ISBN: 9783032102379, February 2026. 

6. Tao Y, Garcia F. M, Sangalli M, Paredes AJ*. Drug delivery to the central nervous system using drug nanocrystals. In Nanocrystals: A Universal Tool for the Formulation of Poorly Soluble Drugs. Springer Nature Switzerland AG. ISBN: 9783032102379, February 2026. 

7. Fuster MG, Tao Y, Sangalli M, Lopez-Vidal L, Paredes AJ*. Overcoming the challenges of mucosal tissues using drug nanocrystals. In Nanocrystals: A Universal Tool for the Formulation of Poorly Soluble Drugs. Springer Nature Switzerland AG. ISBN: 9783032102379, February 2026. 

8. Real DA, Formica M, Picchio M, Paredes AJ*. Manufacturing techniques for nanoparticles in drug delivery. In Drug Delivery Using Nanomaterials. CRC Press/Taylor & Francis. 2022. Doi: 10.1201/9781003168584-2. 

9. Lopez-Vidal L, Real D, Paredes AJ, Real JP, Palma SD. 3D Printed Nanocrystals for Oral Administration of Drugs. In Drug Delivery Using Nanomaterials. CRC Press/Taylor & Francis. 2022. Doi: 10.1201/9781003168584-5.

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Patents 

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1. Camiletti BX, Grosso NR, Allemandi DA, Palma SD, Camacho NM, Paredes AJ, Rago AM, Paredes JA. Nanoformulaciones auto-dispersables para agroquímicos (Self-dispersible Agrochemical Nanoformulations). 20190103690 (2019). Status: granted. 

2. Paredes AJ, Allemandi DA, Palma SD. Dispositivo para producir nanosuspensiones (Dispositive to Produce Nanosuspensions). AR Patent AR118398A4 (2021). Status: granted.